| abstract |
The invention relates to a kind of mitogen-activated protein kinasen n n /ERKn n n Kinasen n n 1/2n n n (n n n MEK1/2n n n ) inhibitors of diarylamine compounds and their use in the preparation of anti-malignant tumor drugs. The diarylamine compound of the present invention is a highly efficient and selectiven n n MEK1/2n n n Kinase inhibitors can be used to prevent or treat malignant tumors, especially in the treatment of melanoma, colorectal cancer, breast cancer, pancreatic cancer, epidermoid tumor, brain tumor and liver cancer. |