http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103565746-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4450e05e2ffe0d0842226377d0108ca4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61J3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 |
| filingDate | 2013-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08fe72197fc01d3a9dadbeee7d000416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c79cfa4d7d8c9336f0737330d6072a54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfc4bb6e4eebdefe35fc155bc8e3d06f |
| publicationDate | 2015-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103565746-B |
| titleOfInvention | Apramycin liposome and preparation method thereof |
| abstract | The invention discloses an apramycin liposome. The apramycin liposome is a composition with a spherical or ellipsoidal double-film structure, and is formed by encapsulating apramycin with a liposome film. A preparation method comprises the following steps: 1) dissolving the apramycin and the liposome film with ethanol to obtain a mixed solution, and dissolving the mixed solution into supercritical CO2 to obtain a supercritical solution, wherein the mass ratio of the apramycin to the liposome film is (1 : 1) to (1 : 30); the liposome film is phosphatidylcholine, or a mixture of phosphatidylcholine and cholesterol; 2) dissolving a stabilizer into an aqueous medium to obtain a stabilizer solution; 3) spraying the supercritical solution to the stabilizer solution at an expansion pressure of 15-30MPa and a pre-expansion temperature of 323-343K, dispersing and precipitating to obtain an apramycin liposome suspension. |
| priorityDate | 2013-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.