http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103554508-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-91 |
| filingDate | 2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103554508-B |
| titleOfInvention | Acid-sensitive amphipathic star-block copolymers, its preparation method and application |
| abstract | The invention discloses a kind of acid-sensitive amphipathic star-block copolymers, its preparation method and application.First, condensation reaction is adopted to prepare the trifunctional alkynyl compounds that phenyl ring is core; For initiator, ring-opening polymerization is carried out to ring-type esters monomer containing the small molecules of alkynyl with one end hydroxyl, the other end again, obtain polyester molecule chain, and be modified into the polyester chain that end contains chlorine functional group; Subsequently, poly glycol monomethyl ether is modified to the molecular chain that end contains acetal radical and azido-; Finally, adopt two steps " CuAAC " click-reaction to prepare acid-sensitive amphipathic star-block copolymers, this polymer architecture and molecular weight controlled, molecular weight distribution is narrower, has good biocompatibility, biodegradability.Multipolymer prepared by the present invention carries hydrophobic anticancer drug by self-assembly bag, and in acid condition, due to the fracture of acetal radical, causes micellar structure to be destroyed, discharge package-contained medicine, can be used as controllable in drug release carrier. |
| priorityDate | 2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.