http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103554121-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49790ed5b8ddc5fa27a1d47732c612df |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95566305917b0a34a873c0e38ca11b2b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_248df9ecd043db65ea913552e8e220e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7909fea45daddf433dc8128f6b25793f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0340350101c82fc2e754aaa07aa5f79c |
| publicationDate | 2015-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103554121-B |
| titleOfInvention | 3,3-spiro (2-tetrahydrofuranyl)-oxindole polycyclic compound and application thereof |
| abstract | The invention discloses a new 3,3-spiro (2-tetrahydrofuranyl)-oxindole polycyclic compound as shown in a formula (I). The new 3,3-spiro (2-tetrahydrofuranyl)-oxindole polycyclic compound is prepared by the following steps: performing (3+2) cycloaddition on isatin diazo, aldehyde and ortho-nitro-substituted phenylene under the catalysis of rhodium acetate to construct an intermediate containing a 3, 3-spiro (2-tetrahydrofuranyl)-oxindole structure, adding a base, and then performing intramolecular Michael addition to further perform ring-closure synthesis. The compound disclosed by the invention has the property of inhibiting the activity of aurora kinase A. |
| priorityDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.