| abstract |
The present invention relates to the substituted fused tricyclic compounds of formula (I) or (Ia), their tautomer, polymorph, stereoisomer, prodrug, solvate, eutectic, the most acceptable salt, comprise their pharmacological compositions, and the patient's condition that mediated by JAK activity and the Therapeutic Method of disease. The compound of the present invention is being treated, is being prevented or suppress in the disease mediated by JAK activity and disorder to be useful.This type of patient's condition includes, but it is not limited to arthritis, alzheimer disease, Autoimmune Thyroid is disorderly, cancer, diabetes, leukemia, T cell prolymphocytic leukemia, lymphoma, myeloproliferative disease, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, septicemia, arthritic psoriasis, carcinoma of prostate, T cell type autoimmune disease, inflammatory diseases, chronic and acute allograft rejection, bone marrow transplantation, apoplexy, asthma, chronic obstructive pulmonary disease, anaphylaxis, bronchitis, viral disease, or type i diabetes, diabetic complication, rheumatoid arthritis, asthma, Crohn disease, xerophthalmia, uveitis, inflammatory bowel, organ-graft refection, psoriasis and ulcerative colitis.Present disclosure further relates to the preparation method of this compounds, and comprises its pharmacological compositions. |