| abstract |
The invention relates to a new roflumilast intermediate compound and a preparation method thereof, and application of the intermediate compound in preparing roflumilast. The roflumilast prepared from the intermediate has the advantages of mild reaction conditions, low requirements for reaction conditions and equipment, fewer byproducts, high product purity and yield and low production cost, does not use palladium on carbon, carbon monoxide or any other high-cost high-toxicity reagent, and is suitable for large-scale industrial production. |