http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103524438-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9251bc5e34fcff569aac7f4e7b8f1e2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 |
| filingDate | 2013-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fad77c156f315b4f4f2f8b0dab01a80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9eebd16cc02264bb5ed973fa4e00a187 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c94ada970afc74609a67d482deec5639 |
| publicationDate | 2014-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103524438-A |
| titleOfInvention | A kind of preparation method of Anastrozole isomer |
| abstract | The present invention relates to a kind of preparation method of anastrozole isomer, and described method comprises the following steps: step 1, anastrozole intermediate bromide reacts with 1.2.4-triazole sodium; step 2, after the reaction is completed, add Hydrochloric acid and toluene, phase separation, the toluene phase is washed with hydrochloric acid; step 3, the hydrochloric acid phase is washed with toluene; step 4, the hydrochloric acid phase is extracted with ethyl acetate, after extraction, the ethyl acetate phase is dried with anhydrous magnesium sulfate, filtered, Concentrate the filtrate to dryness to obtain the crude isomer of anastrozole; step 5, add the crude isomer of anastrozole to dissolve in isopropanol, add activated carbon for decolorization, filter, cool to room temperature for crystallization, and filter to obtain the isomer of anastrozole body. |
| priorityDate | 2013-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.