| abstract |
The invention provides a kind of pharmaceutical preparation of human growth hormone (hGH) polypeptide of Pegylation, does is described polypeptide have the human growth hormone to acetylphenylalanine, wherein saidly replaces hGH in being selected from the position by following formed group acetylphenylalanine: SEQ? ID? the the 35th, 92,131,134,143 and 145 of NO:2; Wherein said acetylphenylalanine to be connected with a linear polyethylene glycol by an oxime key, and the molecular weight of described Polyethylene Glycol is 20kDa ~ 40kDa; Wherein, described preparation is frozen liq; Wherein, the serum half-life of the described hGH polypeptide through Pegylation is at least twice of the natural hGH polypeptide without Pegylation. |