http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103520122-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95474db7a0f95d96758dad5ed9b50036 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10 |
| filingDate | 2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_127a6d6dd59987418ed1d587f955b77a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34330d4a09c735aa2046aa34dc9b233b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be121530219dea02b0822fe42e955625 |
| publicationDate | 2015-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103520122-B |
| titleOfInvention | Preparation method for Bumetanide freeze-dried powder preparation for injection |
| abstract | The invention provides a bumetanide freeze-dried powder preparation for injection and a preparation method thereof. The method consists of: weighing 10ml of glycerol and water for injection in a volume ratio of 1:4-2:3, and stirring them to obtain a latent solvent; weighing 0.5g of bumetanide and dissolving it in the latent solvent, conducting filtering to clarity, thus obtaining a solution A; weighing 200g of mannitol, adding water for injection accounting for 80% of the total amount, carrying out stirring and filtering to clarity, thus obtaining a solution B; mixing the solution A and the solution B evenly, then adding the remaining water for injection to a total amount of 2000ml, performing degerming filtering, then subjecting the product to filling into 1000 10ml tube-type bottles respectively according to a dosage of 2.0ml/bottle; subjecting the tube-type bottles to heat preservation for 4h under -45DEG C; conducting vacuum pumping to a vacuum degree of not greater than 20pa, raising the slab temperature to -5DEG C at a rate of 2DEG C/h, and carrying out heat preservation for 18h; raising the slab temperature to 30DEG C at a rate of 7DEG C/h, and carrying out heat preservation for 2h, thus obtaining the bumetanide freeze-dried powder preparation for injection. According to the invention, the product stability is effectively ensured, the content of impurities is reduced, and the re-dissolubility of the product is good. |
| priorityDate | 2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.