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filingDate 2012-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-103501701-B
titleOfInvention diagnostic brain imaging
abstract A radiological imaging apparatus (10) acquires a radiological brain image of a subject after administration of a radio tracer binding to a target substance indicative of a clinical pathology. In one embodiment, the clinical pathology is amyloid deposits in the brain at a level correlative with Alzheimer's disease and the target substance is amyloid deposits. A processor (C) tests for the clinical pathology by: performing non-rigid registration of the brain image with a positive template (32P) indicative of having the clinical pathology and with a negative template (32N) indicative of not having the clinical pathology; generating positive and negative result metrics (36P, 36N) quantifying closeness of the registration with the positive and negative template respectively; and generating a test result (54) based on the positive result metric and the negative result metric. An independent test result is generated by quantifying a second mode of an intensity histogram for the brain image.
priorityDate 2011-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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