http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103497202-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2013-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103497202-B |
| titleOfInvention | The synthetic method of dorzolamide hydrochloride intermediate |
| abstract | The present invention relates to intermediate compound I a (the 4-ethylamino-5 for the treatment of glaucoma medication dorzolamide hydrochloride, 6-dihydro-6-methyl-4H-thieno-[2,3-b] thiapyran-2-sulphonamide-7,7-dioxide) and Ib (4-ethylamino-5,6-dihydro-6-methyl-4H-thieno-[2,3-b] thiapyran-2-sulphonamide-7,7-dioxide) synthetic method.Ia and Ib is respectively by IIa (4-acetylaminohydroxyphenylarsonic acid 5, 6-dihydro-6-methyl-4H-thieno-[2, 3-b] thiapyran-2-sulphonamide-7, 7-dioxide) and IIb ((4S, 6S)-4-acetylaminohydroxyphenylarsonic acid 5, 6-dihydro-6-methyl-4H-thieno-[2, 3-b] thiapyran-2-sulphonamide-7, 7-dioxide) under the existence of sodium borohydride and iodine, react in a solvent, reduction acetamido is that the mode of ethylamino-is synthesized obtained, the method and published Measures compare, high yield, get rid of hypertoxic raw material, reaction conditions is gentleer, aftertreatment does not have violent heat release or acutely releases gas, decrease the danger of operation. |
| priorityDate | 2013-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.