http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103483583-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-48 |
| filingDate | 2013-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103483583-B |
| titleOfInvention | A kind of preparation method of epsilon-polylysine |
| abstract | The invention discloses a kind of preparation method of novel epsilon-polylysine, the party's genealogy of law take epsilon-polylysine as raw material, in strong polar aprotic solvent, with cyclic acid anhydride generation nucleophilic addition(Adn)-eliminative reaction, gained reaction solution adopts organic solvent precipitation method to obtain product, namely obtains high yield, high percentage of grafting and highly purified novel epsilon-polylysine.Novel epsilon-polylysine of the present invention has a free carboxyl, can with some poorly water-solubles and model drug molecule condensation containing hydroxyl or amino obtains a kind of prodrug, to increase the water-soluble of model drug, this polymkeric substance is expected to as a kind of polymer drug carrier with good aqueous solubility and biocompatibility.The preparation method of novel epsilon-polylysine of the present invention, simple to operate, reaction conditions is gentle, can be used for suitability for industrialized production. |
| priorityDate | 2013-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.