| abstract |
The invention belongs to biological chemistry and biology field, relate to a kind of α O-superfamily conotoxin peptide, its pharmaceutical composition, Preparation Method And The Use.The invention still further relates to the propetide of described conotoxin peptide, its nucleic acid construct, the cell of its expression vector and conversion and its fusion rotein.The invention still further relates to a kind of method of blockage of acetylcholine receptor and the pharmaceutical applications of described conotoxin peptide.The new superfamily conotoxin peptide of α O-of the present invention can blockage of acetylcholine receptor (nAChRs) (such as α 9 α 10 nAChR) specifically, and nmda receptor (such as NR2C NMDAR), and there is treatment neurodynia, the activity of habituation and the activity of cancer chemotherapy, mammary cancer, lung cancer, wound healing, epilepsy, local asphyxia etc., have and preparing the applications well prospect in analgesic, the medicine for the treatment of habituation and neuroscience instrument medicine etc. |