http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103483324-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 |
| filingDate | 2012-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103483324-B |
| titleOfInvention | The new preparation process of lapatinibditosylate |
| abstract | The present invention proposes a kind of method preparing lapatinibditosylate.The method comprises: contacted by compound shown in compound with formula 2 shown in formula 1, compound shown in production 3; Compound shown in formula 3 is reduced, compound shown in production 4; Compound shown in formula 5 is contacted with DMF dimethylacetal, compound shown in production 6; Compound shown in compound with formula 4 shown in formula 6 is contacted, compound shown in production 7; Be there is acid, alkali and NaNH (OAc) in compound shown in compound and formula 9 shown in formula 8n 3 shi Jinhang contacts, compound shown in production 10; And compound shown in compound with formula 11 shown in formula 10 is contacted with during alkali there is catalyzer, generate transition intermediate, and described transition intermediate is contacted with tosic acid with compound shown in formula 7, compound shown in production I.Utilize the method, effectively can prepare lapatinibditosylate. |
| priorityDate | 2012-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.