| abstract |
The invention discloses a preparation method of a 1,4-disubstituted triazole compound, comprising the following steps: adding divalent copper salt, pivalic acid, aromatic amine and substituted acetophenone p-toluenesulfonyl hydrazone into an organic solvent, heated to 100-110° C. to react, and after the reaction is complete, post-treatment to obtain the 1,4-disubstituted triazole compound. The preparation method has simple steps, and the raw materials are easy to obtain, and the reaction does not need to be carried out under anhydrous and oxygen-free conditions, and more importantly, no toxic and explosive azide is needed, and the operation is convenient. |