http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103479576-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 |
| filingDate | 2013-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103479576-B |
| titleOfInvention | A kind of polymine-Polyethylene Glycol-creatine copolymer micelle wrapping up amycin and preparation method thereof |
| abstract | The invention discloses a kind of polymine-Polyethylene Glycol-creatine copolymer micelle wrapping up amycin and preparation method thereof, its preparation method comprises: the two carboxy polyethylene glycol copolymer of synthesis under the effect of pyridine; Amino-Polyethylene Glycol-carboxyl copolymer is combined to again with ethylenediamine Amino End Group; Rear creatine is connected with amino, synthesis creatine-Polyethylene Glycol-carboxyl copolymer; Creatine-Polyethylene Glycol-the carboxyl of activation and polymine are obtained by reacting creatine-PEG-PEI copolymer.Creatine-PEG-PEI micelle is obtained after dialysis.Polymine and creatine on the two ends of Polyethylene Glycol connect, form vesicle parcel amycin using copolymer as pharmaceutical carrier.Amycin is used for the treatment of malignant tumor clinically, but has larger damage to body normal structure organ; Creatine is connected to one end of Polyethylene Glycol by the present invention simultaneously, and amycin is embedded in inside pharmaceutical carrier, and polymine can increase stability on Polyethylene Glycol one end connects. |
| priorityDate | 2013-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.