http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103479573-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103479573-B |
| titleOfInvention | Preparation methods for polyethylene glycol monomethyl ether-polyester diblock copolymer micelle and drug-loaded micelle |
| abstract | The invention provides a preparation method for a drug-loaded nano-micelle. The method comprises the following steps: adding a mixture of a micromolecular drug and an organic solvent into a polyethylene glycol monomethyl ether-polyester diblock copolymer drop by drop so as to obtain a mixed solution; and adding ultrapure water drop by drop when the mixed solution undergoes primary stirring, then subjecting the mixed solution to secondary stirring, carrying out dialysis to remove the organic solvent and then carrying out freeze-drying so as to obtain the drug-loaded nano-micelle. The invention further provides a preparation method for a polyethylene glycol monomethyl ether-polyester diblock copolymer micelle, and the preparation method comprises the following steps: dissolving the polyethylene glycol monomethyl ether-polyester diblock copolymer in an organic solvent, adding ultrapure water drop by drop during primary stirring, then continuing secondary stirring, carrying out dialysis to remove the organic solvent and then carrying out freeze-drying so as to obtain the diblock copolymer micelle. According to the invention, the preparation method for the micelle has the advantages of simple operation and mild conditions; the prepared micelle is in a good monodisperse state, can wrap micromolecular drugs with poor water solubility and enables encapsulation efficiency and dissolvability of the drugs to be improved; and the prepared drug-loaded nano-micelle has a stable structure and is easy to preserve. |
| priorityDate | 2013-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.