| abstract |
The invention provides quaternary ammonium salt compounds of general formula (I), a preparation method thereof, a pharmaceutical composition comprising the compounds as the active components, and the use of the compounds in the preparation of medicaments for treating diseases associated with Lp-PLA2 enzymic activity. In general formula (I), R<1>, R<2>, R<3> are independently C1-4 alkyl, or R<1> is C1-4 alkyl, R<2> and R<3> are taken together to form C4-5 alkylidene groups, and X is F, Cl, Br or I. |