http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103467360-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a483df1d4b5ea677dd937c512c750f2 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 |
| filingDate | 2013-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84647267b69ceb2d3f30aa492a61143b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_822d9f51fb494c9844b929ff491da341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3eca24c9a9615de008f4e7cf943dda40 |
| publicationDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103467360-A |
| titleOfInvention | Morpholine derivatives with cyclopropane structure R-proline and preparation method thereof |
| abstract | The invention provides a method for synthesizing morpholine derivatives with cyclopropane structure R-proline. Ethyl dihydro-2-pyrrolecarboxylate is subjected to Simmons-Smith cyclopropane reaction; in the second step, the enantiomers obtained in the first step are subjected to ester hydrolysis respectively; in the third step, the reaction obtained in the second step The products are respectively subjected to amide condensation reaction; in the fourth step, the reaction products obtained in the third step are respectively subjected to deamination protection reaction; in the fifth step, the reaction products obtained in the fourth step are respectively subjected to reduction reaction; Morpholine derivatives of proline. The method has reasonable process, simple operation and low cost, and does not need further chiral preparation and resolution to obtain optically pure enantiomer products, and is an ideal method for synthesizing morpholine derivatives with cyclopropane structure R-proline . |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106748965-A |
| priorityDate | 2013-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.