| abstract |
The invention provides the liquid pharmaceutical formulation of a kind of aqueous, it comprises people's anti-TNF alpha antibodies or its antigen-binding portion thereof, when described dosage form compared with comprising the most identical preparation of at least one salt and/or at least one buffer agent with injection, alleviate pain at least about 50% relevant to injection in experimenter.Present invention also offers the liquid pharmaceutical formulation of a kind of aqueous, it comprises people's anti-TNF alpha antibodies or its antigen-binding portion thereof, and in subcutaneous administration to object after there is the bioavailability of raising.Described preparation can comprise therapeutic protein, such as people anti-TNF Alpha antibodies or its antigen-binding portion thereof or its biological imitation medicine. |