http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103450339-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b9ed41ec71e1e3d004841f54c9eabd8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 |
| filingDate | 2012-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab9906ee779cc763e050ce3db55369e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4e684638c813b97ad34d060415bc9a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_310205baf5c2fc3564c67a26b238d27f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e81fda2445afb1a1f12a9f5f51c764e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c97de6a01ed3841136b6755059e1090 |
| publicationDate | 2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103450339-B |
| titleOfInvention | LRGD peptide-modified carbolino-hexahydropyrazine-1,4-diketones and their preparation method, antithrombotic effect and use |
| abstract | The invention discloses LRGD peptide-modified carbolino-hexahydropyrazine-1,4-diketones, which are three novel conjugates of carbolino-hexahydropyrazine-1,4-diketone and RGD peptide and are shown in the general formula I. In the general formula I, R represents Leu-Arg-Gly-Asp-Val, Leu-Arg-Gly-Asp-Phe or Leu-Arg-Gly-Asp-Ser. The invention also discloses heterocyclic nucleuses of the novel conjugates, wherein R represents OH. The invention also discloses a preparation method and in-vitro anti-platelet aggregation effects of the novel conjugates, and also discloses an antithrombotic use of the novel conjugates in a rat thrombus formation model. A result shows that the three novel conjugates of the carbolino-hexahydropyrazine-1,4-diketone and the RGD peptide (wherein R represents Leu-Arg-Gly-Asp-Val, Leu-Arg-Gly-Asp-Phe or Leu-Arg-Gly-Asp-Ser) and their heterocyclic nucleuses (wherein R represents OH) have good antithrombotic activity and clear application prospects in antithrombotic agent preparation. |
| priorityDate | 2012-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.