http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103450305-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 2013-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103450305-B |
| titleOfInvention | A kind of synthetic method being prepared steroidal compounds by 3,17-diones steroidal |
| abstract | The invention discloses the synthetic method of steroidal drug and intermediate, particularly relate to a kind of synthetic method being prepared 17-hydroxyl-20-ketone steroidal compounds by 3,17-diones steroidal, belong to pharmaceutical synthesis field.The method is with 3; 17-diones steroidal is raw material; adopt routine, environmental protection, low toxicity reagent; through C3 or (with) selective protection of C11-ketone group; the Wittig reaction of C17 position; selective oxidation 17(20) double bond; after halo displacement; easy high yield prepares steroid drugs cortisone or hydrocortisone or prednisone or Prednisolone Acetate or intermediate 17 alpha-hydroxy-2 0-ketone compounds; aftertreatment is simple, and the three wastes are less, good reaction selectivity; yield is higher, and by-product antiearly pregnancy steroid class medicine and steroid.Raw material is easy to get, and cost is lower, and synthesis technique is simple; Be applicable to suitability for industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109096354-A |
| priorityDate | 2013-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.