| abstract |
The present invention provides a kind of nitrogenous five member ring heterocyclic compound that N- bridging connects and its preparation and purposes, specifically, application the present invention provides the preparation method of the optical isomer of one kind compound shown in formula (I) or the compound, cis-trans-isomer or its pharmaceutically acceptable salt and the series compound and as class I non-steroid androgen acceptor regulator in hyperplasia of prostate, prostate cancer, hirsutism, the alopecia of severe androgen-dependent, acne and other diseases or symptom drug therapy. |