| abstract |
Provided herein is a kind of anti-TGF β RII immunoglobulin list variable domain.Aptly, having the aminoacid sequence as listed by any one of SEQ ID NO:1 38,204,206,208,214,234,236,238,240,263,265,267,269,271,273,275,277,279,281,283,285,287,289 or 291 according to anti-TGF β RII immunoglobulin list variable domain herein, this sequence has most 5 aminoacid replacement, lacks or add.It is also provided herein and conducts relevant disease with TGF signal beta for treatment and be conveniently selected from the polypeptide of disease and the pharmaceutical composition of lower group: tissue fibering, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis；Hepatic fibrosis, including liver cirrhosis and chronic hepatitis；Rheumatoid arthritis；Eye disorders；The fibrosis of skin, including the keloid of skin；Dupuytren's contracture；Renal fibrosis such as nephritis and nephrosclerosis；Wound healing；Reduce cicatrix；And vascular disorder, such as restenosis. |