| abstract |
The present invention relates to the N-hydroxysulfonamide sulfonamide derivatives as the nitre acyloxy donor having physiology to be worth, in other words, the present invention relates to the N-hydroxysulfonamide sulfonamide derivatives that nitre acyloxy (HNO) can be provided under physiological conditions, they may be used for treating and/or preventing to the disease of nitroxyl therapy response or the outbreak of illness and/or process, and described disease comprises in heart failure and local ischemia/reperfusion injury.New N-hydroxysulfonamide sulfonamide derivatives can be controlled quick-release and puts NHO under physiological conditions, and the speed of HNO release can be regulated by the position of the character and functional group that change N-hydroxysulfonamide sulfonamide derivatives. |