http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103435523-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8214b4c73bbb9cd03a4b7b0c5ef8c4a8 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-32 |
filingDate | 2013-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e15477f8200fc535d050a2e3e3563ad2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6044c856c89eb5ceff728df04bb4aee5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b531b9fcb919966c205958acc2f3a698 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a33d6a5beba9bd595768841722dd3b |
publicationDate | 2013-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-103435523-A |
titleOfInvention | Preparation method of (1R,2S)-2-fluoro-cyclopropylamine p-toluenesulfonate |
abstract | The invention provides a preparation method of compound (I) (1R, 2S)-2-fluoro-cyclopropylamine p-toluenesulfonate, comprising the steps of: reacting compound (II) with vinyl acetate to obtain compound (III); compound (III) reacts with Grignard reagent to obtain compound (IV); compound (IV) reacts with methyl iodide to obtain compound (V); compound (V) reacts with dibromofluoromethane to obtain compound (VI); compound (VI) debromination Compound (VII) is obtained; Compound (VII) is recrystallized to obtain Compound (VIII); Compound (VIII) is demethylated to obtain Compound (X); Compound (X) is reduced to obtain Compound (XI); Compound (XI) and p-toluenesulfonate Acid reaction obtains compound (XII); compound (XI) reacts with L-menthyl chloroformate to obtain compound (XIII); (k) compound (XIII) reacts with p-toluenesulfonic acid to obtain target product compound (I); the present invention The method has low cost and high yield, and is suitable for industrial production. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113493386-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113493386-A |
priorityDate | 2013-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.