http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103425859-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7610cef0de1410bf21e1e54706e208a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 |
| filingDate | 2012-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f252f139e5c6c7a2c888fa50a1d27d58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_010106fe4ecd619068b6a030bfc0ec3a |
| publicationDate | 2013-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103425859-A |
| titleOfInvention | Screening method of TTR (transthyretin) small-molecule inhibitors |
| abstract | The invention aims to establish an efficient, fast and reliable screening method of TTR (transthyretin) small-molecule inhibitors, overcomes the defects of the prior art and is applicable to design of medicines for amyloidosis caused by TTR fibrosis. A small-molecule database is screened and predicted by means of 3D-QSAR (3-dimensional quantitative structure activity relationship), molecular docking, pharmacophore models and the like; small molecules capable of serving as lead compounds are determined preliminarily; further cell screening is performed. The screening method is fast and efficient; a plurality of drug screening and design methods based on receptors and ligands are applied; accordingly, reliability of screening results is improved greatly. Cell levels are subjected to biological screening by lead compounds obtained by screening, so that screening speed is higher and development and search cycle of novel inhibitors is shortened. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108701171-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108875298-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108875298-A |
| priorityDate | 2012-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.