| abstract |
The invention discloses a method for synthesizing two metabolites of the anti-stroke drug pinocerine, to obtain pinocerin-7-O-β-D-glucuronic acid and pinocerin-7-O- Sodium sulfonate two compounds. Pinoccelin-7-O-β-D-glucuronic acid uses pinoccelin as raw material, after acetylation protection, then selective deprotection, and finally combined with tri-O-acetyl-α-D- Glycosidation of methyl bromoglucuronate, followed by deprotection to obtain the target compound. Pinocerine-7-O-sodium sulfonate uses pinocerine as a raw material, uses pyridine as a solvent and a catalyst at the same time, performs a sulfonation reaction with chlorosulfonic acid, and then forms a salt to obtain the target compound. The above two target compounds can provide standards for studying the metabolic pathway of pinocerin. |