http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103420979-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2012-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103420979-B |
| titleOfInvention | The process for purification of Esomeprazole sodium |
| abstract | The present invention relates to a kind of process for purification of Esomeprazole sodium.The process for purification of a kind of Esomeprazole sodium of the present invention, for from prochiral compound-thioether, through Esomeprazole sodium crude product refining of asymmetric oxidation reaction synthesis.Described process for purification comprises the following steps: with the Esomeprazole sodium crude product synthesized by asymmetric oxidation reaction for raw material, by rudimentary organic ketone by after described Esomeprazole sodium dissolving crude product, then add acetonitrile, after precipitation to be crystallized, filter, obtain first subcrystalline highly finished product; By above-mentioned highly finished product with after rudimentary Organic Alcohol heating for dissolving, cooling, after precipitation to be crystallized, filters, obtains second subcrystalline highly finished product; The optical purity of the Esomeprazole sodium highly finished product obtained brings up to more than 99.8% by 92% of crude product, and content is up to more than 99.5%. |
| priorityDate | 2012-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.