http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103420856-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc6cfe4fdb4a9d54ba1fa2f06996abfc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c289ba04f80d26048b0d016b4e6f7b55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fdb18a9ebc66482a464f09a4d1b8624 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5818117b7efc4122905018b3abdc5210 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_002d51d6d3f9317d05d9e408d3f7feb3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 |
| filingDate | 2013-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc9f9fb18ef0f19300e3692e23c99b0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fa65831b9a28f8ed470c63479e08f9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_919002364ddfce36597ea402369fd5a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69d667880569c791ff471d9cc85b03c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cafd6f405df20be9a460bd61c946d87f |
| publicationDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103420856-B |
| titleOfInvention | Salmeterol preparation method |
| abstract | The invention discloses a salmeterol preparation method which aims to overcome the defects in the prior art. According to the preparation method, 2-bromine ethylbenzene, which is easier to obtain, is taken as raw material, and the key intermediate 4-phenylbutanol is obtained through condensation, decarboxylation and reduction of 2-bromine ethylbenzene and malonic acid ester; N-benzyl-6-(4-phenyl butyl)-hexylamine is obtained through two-step condensation of 4-phenylbutanol; the key intermediate 5-[2-(benzyl (6-(4-phenyl butyl) hexyl) amino) acetyl] salicylaldehyde is obtained through condensation of N-benzyl-6-(4-phenyl butyl)-hexylamine and 5-chloracetyl-salicylaldehyde; finally, the salmeterol is obtained through simple steps of reduction, deprotection, salifying and the like. According to the preparation method, the technology is stable, the reaction condition is moderate, the selectivity is excellent, the aftertreatment is simple to operate, the intermediates are easily to separate, and the product has high purity and high yield, so that a novel thinking and a novel method for large-scale production of salmeterol are provided. |
| priorityDate | 2013-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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