| abstract |
Disclose compound of formula I with and the like, prodrug, the isotope analog, pharmaceutically acceptable salt, polymorph, solvate, isomer, inclusion compound and the eutectic that replace, as nAChR in the object for needing treatment, the especially conditioning agent of the hypotypes of α 7, individually or with suitable other therapeutic combinations use, wherein, Z, m and R 1 ‑R 6 As defined herein, and the pharmaceutical composition containing this kind of compound and analog.The preparation technology and its purposes in the treatment of this kind of compound are also disclosed, the diseases such as such as degenerative brain disorder, mild cognitive impairment, senile dementia are especially prevented and treated. |