http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103396443-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6512 |
| filingDate | 2013-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103396443-B |
| titleOfInvention | A kind of preparation method of tynofovir |
| abstract | Present invention is disclosed a kind of tynofovir (Tenofovir, I) preparation method, its preparation process comprises: 4, it is amino that the chloro-5-nitro-pyrimidine (II) of 6-bis-and-2-(diethoxy phosphatidyl methoxy) propane (III) condensation of (R)-1-amino generate (R)-4-{N-[2-(diethoxy phosphatidyl methoxy) propyl group] }-5-nitro-6-chloropyrimide (IV), intermediate (IV) generates (R)-1-(6-chloropurine-9-base)-2-(diethoxy phosphatidyl methoxy) propane (V) through reductive ring closure, intermediate (V) generates (R)-1-(adenine-9-base)-2-(diethoxy phosphatidyl methoxy) propane (VI) through ammonia solution, intermediate (VI) obtains tynofovir (I) through hydrolysis reaction.This preparation method's raw material is easy to get, concise in technology, and side reaction is few, is applicable to suitability for industrialized production. |
| priorityDate | 2013-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.