http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103396344-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab0a995e05f15485bdffcdd45c550b49 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C273-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-16 |
| filingDate | 2013-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5b25bbfbf4c64778a730c6a85369c00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c4cdf5d590f03c9c8a027c31b2d5a6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0fc93454ad2e2f5b09084d0f9e31095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89c1f422183d38bcdee1ac5ca2da86d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca335fc520ba86eba3f1dc06bbd6a32c |
| publicationDate | 2013-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103396344-A |
| titleOfInvention | One-pot method for synthesizing N-tert-butylaminocarbonyl-3-methyl-L-valine |
| abstract | The invention relates to a method for synthesizing N-tert-butylaminocarbonyl-3-methyl-L-valine, an intermediate of boceprevir, in one pot, and belongs to the technical field of drug synthesis. The synthesis method includes the following steps: dissolving tert-butylamine in a solvent to form a reaction solution, cooling the reaction solution to -5°C to 5°C, first adding N,N'-carbonyldiimidazole to the reaction solution, and reacting under stirring 20min~40min until the reaction is complete to obtain the compound of formula (I); then add L-leucine to the reaction solution, and react under stirring for 20min~40min until the reaction is complete, then add the reaction solution to ice water and extract , concentration under reduced pressure, beating, suction filtration, and vacuum drying to obtain N-tert-butylaminocarbonyl-3-methyl-L-valine. The raw materials used in the synthesis method are cheap and easy to obtain, environmentally friendly, simple reaction conditions, high conversion rate, few by-products, and high product yield and purity. |
| priorityDate | 2013-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.