http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103394125-B

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56
filingDate 2013-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c138a96b8293342d774c6e8affd5ccec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a60f540cb4580fbc8eb714edffdfa239
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publicationDate 2015-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-103394125-B
titleOfInvention Tissue engineering double-layered tubular support and preparation method thereof
abstract The invention relates to a tissue engineering double-layered tubular support and a preparation method thereof. The support is composed of two polymer layers with different pore structures, the inner layer is a compact nanofiber structure, and the outer layer is of a porous nanofiber structure. The preparation method comprises the following steps of: dissolving a polymer material in a solvent, pouring in a mould, performing phase separation overnight, demoulding to obtain a polymer gel, performing solvent replacement, and freeze drying to obtain a nanofiber tubular support with a compact structure; sleeving the nanofiber tubular support on a mould stem to obtain a casting mould; and dissolving a polymer material in a solvent, casing the polymer solution in the casing mould by combing an electroporation technology, performing phase separation overnight, demoulding, performing solvent replacement, removing the solvent and/or porogen, and freeze drying to obtain the tissue engineering double-layered tubular support. The preparation method disclosed by the invention is simple in operation, free of complicated equipment, suitable for large-scale production and low in preparation cost; the whole mechanical property of the support is improved by introducing other polymers in the phase separation system.
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