http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103387560-B
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4711b7defc1422cdb7f86d2c95657bf |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 |
filingDate | 2013-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d88d42f179cbd466f92224a618fd0263 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a50244480dab83e52bf0e01ed3dffe8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_071a40f5296059cfeae95e796547d516 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_590f7a99b00ee994c8f310b1709459e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4df29c60d515cada5899612f00894b87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b03afd962420a9e596080ab6a0ad00ff |
publicationDate | 2015-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-103387560-B |
titleOfInvention | Preparation method of 2-[(4R, 6S)-6-substitued methyl-2, 2-dimethyl-1, 3-dioxan]-acetate |
abstract | The invention belongs to the technical field of organic chemistry, and specifically relates to a preparation method of 2-[(4R, 6S)-6-substituted methyl-2, 2-dimethyl-1, 3-dioxan]-acetate. The preparation method specifically comprises: performing asymmetric epoxidation on (S)-1-substituted-4-ene-2-pentanol (II) to prepare (2S, 4R)-1-substituted-4-epoxy-2-pentanol (III); performing sodium cyanide ring-opening addition to prepare (3S, 5S)-6-substituted-3, 5-dihydroxyacetonitrile; performing a Pinner reaction to prepare (3S, 5S)-6-substituted-3, 5-dihydroxyhexanoate; and then performing a protection reaction with 2, 2-dimethoxypropane to prepare 2-[(4R, 6S)-6-substitued methyl-2, 2-dimethyl-1, 3-dioxan]-acetate (I). The preparation method of the invention is mild in reaction conditions, simple in operation, cheap and easily-available in raw materials, high in yield of the obtained product and high in stereoselectivity, and is applicable to industrialized production. |
priorityDate | 2013-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 440.