http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103382213-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18086029ee284d70cc9ce46d117d4ff3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_240aeca36abde0438262a8d5055d5961 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beb305f2e8f575e0c9d4a4bc9a837ca9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a241b2ef2620a47b6454b9e16757d060 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af57a0d546575e9304700335b8d1c5c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e403a0c759dc49e5df90c7f373937839 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e77dd6b01d734ee7dd54a9e267f091f |
| publicationDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103382213-B |
| titleOfInvention | 17-(2', 5'-disubstituted oxazolyl)-androstane-4, 16-diene-3-ketone, and preparation method and applications thereof |
| abstract | The invention discloses 17-(2', 5'-disubstituted oxazolyl)-androstane-4, 16-diene-3-ketone, and a preparation method and applications thereof. The preparation method comprises a following step: 17-ethynyl-androstane-4, 16-diene-3-ketone and a nitrile compound are subjected to catalytic reaction in the presence of oxidizing agent 8-methylquinoline-N-oxide and gold catalyst so as to obtain 17-(2', 5'-disubstituted oxazolyl)-androstane-4, 16-diene-3-ketone. The preparation method is simple and is suitable for industrial production; speed is fast; and yield is high. Obtained 17-(2', 5'-disubstituted oxazolyl)-androstane-4, 16-diene-3-ketone is used as an active ingredient in preparation of antitumor drugs which possess inhibitory activity on human hepatoma cells, human lung cancer cells, human cervical carcinoma cells, human breast cancer cells and human prostatic cancer cells. |
| priorityDate | 2013-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.