abstract |
The invention belongs to the technical field of medicine, and specifically relates to pyridonaphthyridine derivatives represented by general formula (I) as HDAC and mTOR inhibitors, pharmaceutically acceptable salts thereof, and isomers thereof: wherein A, X , Y, W, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the description; the present invention also relates to the preparation methods of these compounds, and the pharmaceutical preparations containing these compounds And pharmaceutical compositions, and the application of these compounds in the preparation of medicines for treating and/or preventing diseases related to HDAC and MTOR activity. |