http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103360356-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-94 |
| filingDate | 2012-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103360356-B |
| titleOfInvention | A kind of intermediate of drospirenone and preparation method thereof with its drospirenone preparation in application |
| abstract | The invention discloses a kind of intermediate of drospirenone and preparation method thereof with its drospirenone preparation in application.Described intermediate has following chemical structure of general formula:n r in general formula is H, Li, Na, K, 1/2Mg, 1/2Ca, NHn 4 , CHn 3 , CHn 2 cHn 3 , CHn 2 cHn 2 cHn 3 , CH (CHn 3 )n 2 , CHn 2 cHn 2 cHn 2 cHn 3 , CHn 2 cH (CHn 3 )n 2 or CH (CHn 3 )n 3 .The preparation of described intermediate comprise step in following synthetic route 3. or step 2. ~ 3. or step 1. ~ 3.:n added in the organic solvent and water dissolved each other with water by described intermediate of drospirenone, be heated to backflow, back flow reaction terminates, and cools to room temperature, frozen water crystallization, filters, and dries, can obtain drospirenone.The preparation of intermediate of the present invention and utilizing all without the need to re-using Heavy Metal Reagent and poisonous reagent in the process of this Intermediate Preparation drospirenone, and preparation is simple. |
| priorityDate | 2012-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.