http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103360338-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d2edff2a09f26d9b6aabeb85262e8cb |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 |
| filingDate | 2013-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e3c18a964830d996019265c1653909f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cedcf69de824464bc7cb194687f808a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3f67c8addffe359fb0ab92d3a532696 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e576a87672b81a287dba28e372e9ddf |
| publicationDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103360338-B |
| titleOfInvention | Preparation method of chalconebenzothiazoleamide derivatives, and use of derivatives |
| abstract | The invention relates to a preparation method of chalconebenzothiazoleamide derivatives, and a use of the derivatives. The preparation method comprises the following steps: carrying out a ring closure reaction of a raw material different substituted aminochalcone, liquid bromine and potassium rhodanate under the catalysis of an acid to generate corresponding chalconebenzothiazoleamine; and reacting the chalconebenzothiazoleamine with benzoic acid under the action of condensing agents comprising N,N-dicyclohexyl carbodiimide, p-dimethylaminopyridine and 1-hydroxybenzotriazol to synthesize the derivatives. Results of experiments on the tyrosinase activity test of the above synthesized new compounds show that compounds 2d and 3b have certain tyrosinase activation activities, a compound 3d has a good tyrosinase activation activity, and the EC50 of the compound 3d is less than a positive medicine 8-methoxy psoralen. The method has the advantages of mild reaction conditions and simple experiment steps; and the chalconebenzothiazoleamide derivatives obtained through the method can be used for preparing leucoderma treatment medicines. |
| priorityDate | 2013-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 108.