http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103360327-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-36 |
| filingDate | 2012-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103360327-B |
| titleOfInvention | A kind of phenonaphthazine derivative and its preparation method and application |
| abstract | The invention belongs to medicine and chemical field, disclose a kind of phenonaphthazine analog derivative and preparation method thereof and the purposes as cancer therapy drug.This phenonaphthazine derivative as shown in structural formula (I), wherein Rn 1 , Rn 2 for H, halogen ,-OCHn 3 or-NOn 2 ; And Rn 1 , Rn 2 =-O-CHn 2 -O-; N=1 or 2; R represents various aliphatic amide, comprises chain and ring-shaped fat amine.The present invention discloses the preparation method of this phenonaphthazine derivative and the purposes as cancer therapy drug thereof, this phenonaphthazine derivative has very strong restraining effect to topoisomerase I and topoisomerase II, to multiple JEG-3, there is significant restraining effect, have wide application space preparing on cancer therapy drug. |
| priorityDate | 2012-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.