| abstract |
The present invention provides aminopurine compounds having the following structural formula (I), wherein R 1 , R 2 and R 3 are as defined herein, and compositions comprising an effective amount of the aminopurine compounds. The present invention also provides compounds and compounds for treating or preventing cancer, cardiovascular disease, renal disease, autoimmune disease, inflammatory disorders, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, asbestos-related disorders , pulmonary arterial hypertension, or a method for treating or preventing a disease by inhibiting the JNK pathway, the method comprising administering an effective amount of an aminopurine compound to a patient in need thereof: |