| abstract |
The invention discloses an angiogenesis protein and an application thereof, and belongs to the biological technology and medical field. The mRNA coded by the angiogenesis protein is found to be expressed in a vascular endothelial cell, and the expression of the protein in the vascular endothelial cell is determined by preparing polyclonal antiserum of the protein, so that a plurality of methods for expressing and preparing the protein are established. Moreover, the recombinant and expressed protein is firstly found to be capable of prompting the migration and tubular formation of the vascular endothelial cell, so that the generation of vascular endothelial cell NO can be stimulated. The angiogenesis protein disclosed by the invention can be applied in preparing therapeutic drugs of heart disease and atherosclerosis caused by tissue-organ ischemia reperfusion injury repair, myocardial infarction, cerebral infarction and diabetes mellitus as well as drug development during a wound healing process and an organ transplanting process. |