http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103342654-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7641d8ec4b289baa8268f4936e0e4635 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-30 |
| filingDate | 2013-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c795bb377f56dda015d26a7b74b53d95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fc45ff68b6f81106d6bdd420c8580f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c162e2483399b5269f3ade47e0a4123e |
| publicationDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103342654-B |
| titleOfInvention | Novel method for hydrolyzing nitrile group to acylamino |
| abstract | The invention relates to a novel method for hydrolyzing nitrile grouping to acylamino. The method comprises the following steps: adding a nitrile compound, N,N'-Di-n-amyl bromide benzimidazole,1,8-Diazabicyclo[5.4.0]undec-7-ene with a mol ratio of 1:0.05:0.05 into water, uniformly stirring, heating and carrying out heat preservation on reaction liquid until the reaction of the reaction liquid is finished, removing water, and performing thin-layer chromatography separation on residues to obtain amide compounds. According to the method provided by the invention, such original defects as long reaction time, liability to generation of side reactions, harsh reaction conditions and environmental pollution are overcome. The method provided by the invention is moderate in conditions, high in selectivity and short in reaction time, no traditional strong acid or strong alkali is used as a catalyst, the nitrile grouping is completely converted to the acylamino, no further hydrolysis to produce carboxyl by-products is generated and the catalyst is cheap and easy to obtain. |
| priorityDate | 2013-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.