| abstract |
The invention provides a stable compound coenzyme preparation and a preparation method thereof for the first time. The stable compound coenzyme preparation comprises the following main components in proportions: 90U to 120U of coenzyme A (Co A), 0.1mg/ml to 0.3mg/ml of coenzyme I (NAD), 1mg/ml to 5mg/ml of glutathione (GSH), 1mg/ml to 2.5 mg/ml of adenosine triphosphate (ATP), 1.8mu g/ml to 12mu g/ml of flavin mononucleotide (FMN), 3mu g/ml to 13mu g/ml of flavin adenine dinucleotide (FAD), 0.1mg/ml to 0.4mg/ml of adenosine diphosphate (ADP), 0.2mg/ml to 0.4mg/ml of adenosine monophosphate (AMP), 1.2mu g/ml to 15mu g/ml of S-adenosylmethionine (SAM), 1mg/ml to 5mg/ml of calcium gluconate, 0.5mg/ml to 1.5mg/ml of cysteine hydrochloride and 0.6mg/ml to 5mg/ml of mannitol. In addition, according to the preparation method, the defects that the freeze-drying condition is not clear and the product stability is poor due to the adoption of high-speed centrifugation in an existing method are overcome. The stable compound coenzyme preparation and the preparation method thereof can be widely applied to the practices for preparing medicines for treating cardio-cerebrovascular diseases and digestive system diseases. |