http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103340823-B

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filingDate 2013-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c47b7b7b5956e2fc9f6ca4230e7f8aa
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publicationDate 2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-103340823-B
titleOfInvention Formulation of paeonol proniosomes and preparing method thereof
abstract The invention discloses a formulation of paeonol proniosomes and a preparing method thereof. The preparing method comprises the steps: firstly, dissolving 3 to 6 parts of paeonol, 64 to 145 parts of a non-ionic surfactant, 64 to 145 parts of lecithin and 7 to 13 parts of cholesterol into 1 to 3 parts of an organic phase, capping and sealing, and heating in a water bath to dissolve all the ingredients completely; and then adding 1-3 parts of an aqueous solution, heating in the water bath again to form a clear solution, and cooling to the room temperature to obtain the paeonol proniosomes. The paeonol proniosomes are in a semi-solid gel state, can be recombined to form non-ionic surfactant niosomes after hydration, provide a effective method for solving the problems of easy aggregation and easy fusion of niosomes and leakage of drugs in a solution state and a storage process of the non-ionic surfactant noisomes, have obvious superiorities in transportation, storage and use, are suitable for industrial production, and are used as quite promising novel carriers. The paeonol proniosomes can be directly applied to skins, and also can be prepared into a gel agent, an ointment, a patch and other transdermal drug delivery formulations.
priorityDate 2013-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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