http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103333180-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-06 |
| filingDate | 2013-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103333180-B |
| titleOfInvention | Preparation method of aspoxicillin |
| abstract | The invention discloses a preparation method of aspoxicillin, and belongs to the field of chemical medicine synthesis. The preparation method comprises following steps: D-aspartic acid and amoxycillin are taken as raw materials; D-aspartic acid is subjected to methyl esterification and methylamination; ethyl acetoacetate is used for amino protection; chloroformate is used for preparing a mixed anhydride; the mixed anhydride is reacted with amoxicillin triethylamine salt, and then is subjected to hydrolyzation for deprotection as to obtain aspoxicillin. Ethyl acetoacetate is used for protecting amino group of D-2-amino-3-methylaminocarbonyl propionic acid, chloroformate is reacted with D-2-(2-methoxycarbonyl-1-methyl vinyl)amino-3-methyl aminocarbonyl propionic acid as to obtain the mixed anhydride, and the mixed anhydride is reacted with amoxicillin amino group. Aftertreatment is simplified, and production cost is reduced significantly. |
| priorityDate | 2013-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.