| abstract |
The invention discloses an amide compound, a preparation method and application thereof. The structural formula of amide compounds is shown in formula I or formula II, in which, R1 and R2 both represent H, methyl, trifluoromethyl or halogen, and R1 and R2 are the same or different; R3 represents H , hydroxymethyl, aminomethyl or C 1-2 alkyl carboxylate; R 4 represents H, methyl or isopropyl; X represents CH, N or O, and n is an integer between 0 and 3. The present invention also provides pharmaceutically acceptable salts of the amide compounds represented by formula I or formula II. The preparation method provided by the present invention starts from simple and easy-to-obtain raw materials, and obtains imidazol[1,2-a][1,8]-naphthyridine amide compounds through 4 to 5 steps of reaction; the amide compounds provided by the present invention It has good activity of inhibiting HCV virus. |