http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103330936-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-29 |
| filingDate | 2013-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103330936-B |
| titleOfInvention | A kind of Aluminium phosphate adjuvant in-situ method prepares the method for Hepatitis B virus vaccine |
| abstract | The present invention relates to a kind of method that Aluminium phosphate adjuvant in-situ method prepares Hepatitis B virus vaccine.Comprise the following steps: 1) aluminum trichloride solution, water, sodium chloride solution, hepatitis B surface antigen stock solution are added in reactor successively and be uniformly mixed; 2) in step 1), add the mixed solution of sodium hydrogen phosphate and sodium hydroxide, and stir.Vaccine particle diameter prepared by the inventive method is the polydispersity system of about 45nm, the uniform particles of vaccine, exquisiteness, in the body of vaccine, the good stability of external relative effectivenes and vaccine; This method production technology cycle is short, technological operation simple, low cost of manufacture, is beneficial to large-scale production. |
| priorityDate | 2013-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.