http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103320500-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd4bdb71dd03dcdbec9fda2d3ae1dbb5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-66 |
| filingDate | 2013-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40ae737fbf80c00fd759a779421f216d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c9aad35fe8ba4ef13f5d67ddb1d0dc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d441e567489652b48a351becac9e5b5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be0a7b176db74fc510d826b11501105a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f61c31ab536c96b28aadaa75a6660082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b19fc3499afc45efd7fcd1c20402e48 |
| publicationDate | 2013-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103320500-A |
| titleOfInvention | Method for promoting colorectal cancer (CRC) distant metastasis by microRNA-29a through KLF4 |
| abstract | The invention discloses a method for promoting colorectal cancer (CRC) distant metastasis by microRNA-29a through KLF4. The method comprises the following steps of 1, preparing a tissue sample, 2, carrying out RNA extraction and real-time quantitative reverse transcription PCR, 3, carrying out cell culture and transfection, 4, carrying out a luciferase test, 5, carrying out western blotting, 6, carrying out cell invasion and 7, carrying out statistical analysis. Expression of miR-29a in CRC tissue is related with CRC distant metastasis; miR-29a expression improvement points out poor prognosis and combination of miR-29a expression improvement and KLF4 expression decreasing further points out poor prognosis; and a mechanism research shows that miR-29a promotes CRC cell invasion by acting on KLF4. The method provides a theoretical basis for miR-29a-based CRC patient prognosis evaluation and for miR-29a inhibitor-based CRC distant metastasis treatment. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104611429-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103966328-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113134077-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104611429-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103966328-A |
| priorityDate | 2013-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 171.