http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103319597-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 |
| filingDate | 2013-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103319597-B |
| titleOfInvention | Insulin-like growth factor-1 receptor (IGF-1R) resistant antibody and coding genes and applications thereof |
| abstract | The invention discloses an insulin-like growth factor-1 receptor (IGF-1R) resistant antibody and coding genes and applications thereof. Amino acid sequences of three hypervariable regions CDRH1, CDRH2 and CDRH3 of a heavy-chain variable region of the IGF-1R resistant antibody are respectively: GYSISSGYYWG, NIYHSGSTNYNPSLKS, and QGGSYSTDY, and the amino acid sequences of three hypervariable regions CDRL1, CDRL2 and CDRL3 of light-chain variable region are respectively: SGSRSNIGSNPAN, SNNQRPS and SSWDDSLNGP. Nucleotide sequences of coding genes of the heavy-chain variable region and the light-chain variable region are shown as SEQ ID No.1 and 3. The applications are applications of the IGF-1R resistant antibody in preparation of antitumor drugs. Compared with the prior art, the IGF-1R resistant antibody can effectively inhibit growth of tumor cells with high-expression of the IGF-1R. |
| priorityDate | 2013-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 349.